Magnetic steering control of multi-cellular bio-hybrid microswimmers

Show simple item record Carlsen, Rika Wright Edwards, Matthew R. Zhuang, Jiang Pacoret, Cecile Sittis, Metin 2017-03-08T17:20:44Z 2017-03-08T17:20:44Z 2014-06-17
dc.identifier.citation Magnetic steering control of multi-cellular bio-hybrid microswimmers RW Carlsen, MR Edwards, J Zhuang, C Pacoret, M Sitti - Lab on a Chip, 2014 en_US
dc.description.abstract Bio-hybrid devices, which integrate biological cells with synthetic components, have opened a new path in miniaturized systems with the potential to provide actuation and control for systems down to a few microns in size. Here, we address the challenge of remotely controlling bio-hybrid microswimmers propelled by multiple bacterial cells. These devices have been proposed as a viable method for targeted drug delivery but have also been shown to exhibit stochastic motion. We demonstrate a method of remote magnetic control that significantly reduces the stochasticity of the motion, enabling steering control. The demonstrated microswimmers consist of multiple Serratia marcescens (S. marcescens) bacteria attached to a 6 μm-diameter superparamagnetic bead. We characterize their motion and define the parameters governing their controllability. We show that the microswimmers can be controlled along two-dimensional (2-D) trajectories using weak magnetic fields (≤10 mT) and can achieve 2-D swimming speeds up to 7.3 μm s−1 . This magnetic steering approach can be integrated with sensory-based steering in future work, enabling new control strategies for bio-hybrid microsystems. en_US
dc.language.iso en_US en_US
dc.publisher Lab on a chip en_US
dc.subject Bio-hybrid devices en_US
dc.subject actuation en_US
dc.subject bio-hybrid microswimmers en_US
dc.subject challenges en_US
dc.subject trajectories control en_US
dc.subject magnetic steering en_US
dc.title Magnetic steering control of multi-cellular bio-hybrid microswimmers en_US
dc.type Article en_US

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