The importance of structural anisotropy in computational models of traumatic brain injury

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dc.contributor.author Carlsen, Rika Wright
dc.contributor.author Daphalapurkar, Nitin P.
dc.date.accessioned 2017-03-08T16:52:16Z
dc.date.available 2017-03-08T16:52:16Z
dc.date.issued 2015-02-19
dc.identifier.citation The importance of structural anisotropy in computational models of traumatic brain injury RW Carlsen, NP Daphalapurkar - Frontiers in neurology, 2015 en_US
dc.identifier.uri http://hdl.handle.net/11347/185
dc.description.abstract Understanding the mechanisms of injury might prove useful in assisting the development of methods for the management and mitigation of traumatic brain injury (TBI). Computational head models can provide valuable insight into the multi-length-scale complexity associated with the primary nature of diffuse axonal injury. It involves understanding how the trauma to the head (at the centimeter length scale) translates to the white-matter tissue (at the millimeter length scale), and even further down to the axonal-length scale, where physical injury to axons (e.g., axon separation) may occur. However, to accurately represent the development of TBI, the biofidelity of these computational models is of utmost importance. There has been a focused effort to improve the biofidelity of computational models by including more sophisticated material definitions and implementing physiologically relevant measures of injury. This paper summarizes recent computational studies that have incorporated structural anisotropy in both the material definition of the white matter and the injury criterion as a means to improve the predictive capabilities of computational models for TBI. We discuss the role of structural anisotropy on both the mechanical response of the brain tissue and on the development of injury. We also outline future directions in the computational modeling of TBI. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers in Neurology en_US
dc.subject Traumatic brain injury en_US
dc.subject Diffuse axonal injury en_US
dc.subject Computational model en_US
dc.subject Injury criterion en_US
dc.subject Axonal strain en_US
dc.title The importance of structural anisotropy in computational models of traumatic brain injury en_US
dc.type Article en_US


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