pH-Taxis of Biohybrid Microsystems

Show simple item record Zhuang, Jiang Carlsen, Rika Wright Sitti, Metin 2017-03-08T16:13:18Z 2017-03-08T16:13:18Z 2015-06-15
dc.identifier.citation pH-taxis of biohybrid microsystems J Zhuang, RW Carlsen, M Sitti - Scientific reports, 2015 en_US
dc.description.abstract The last decade has seen an increasing number of studies developing bacteria and other cell-integrated biohybrid microsystems. However, the highly stochastic motion of these microsystems severely limits their potential use. Here, we present a method that exploits the pH sensing of flagellated bacteria to realize robust drift control of multi-bacteria propelled microrobots. Under three specifically configured pH gradients, we demonstrate that the microrobots exhibit both unidirectional and bidirectional pH-tactic behaviors, which are also observed in free-swimming bacteria. From trajectory analysis, we find that the swimming direction and speed biases are two major factors that contribute to their tactic drift motion. The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems. Furthermore, assuming that it is possible to tune the preferred pH of bioactuators by genetic engineering, these biohybrid microsystems could potentially be applied to sense the pH gradient induced by cancerous cells in stagnant fluids inside human body and realize targeted drug delivery. en_US
dc.language.iso en_US en_US
dc.publisher Scientific reports en_US
dc.subject Biohybrid microsystems en_US
dc.subject Microsystem control en_US
dc.subject bioactuators behavior en_US
dc.subject bacterial chemotaxis en_US
dc.subject pH level en_US
dc.subject control of multi-bacteria en_US
dc.subject pH gradient generation en_US
dc.subject Swimming speed en_US
dc.title pH-Taxis of Biohybrid Microsystems en_US
dc.type Article en_US

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